Abstract
Obstructive sleep apnea (OSA) may occur in patients with achondroplasia. Since the bulk of growth hormone (GH) is secreted in relation to slow wave (non REM) sleep, disordered sleep may interfere with GH release and subsequent growth. To examine the relationship between sleep apnea and growth we studied a 9 yr old achondroplastic dwarf with growth failure (>-3SD on achondroplasia growth curve) and OSA. Polysomnography with q 20 min. sampling for sleep entrained GH was performed before and 4 mos. after therapeutic tracheostomy (T).
Thus correction of sleep apnea normalized sleep stages in this patient and led to significantly increased sleep entrained growth hormone secretion resulting in normalization of growth rate. Caloric intake was unchanged before and after tracheostomy. Conclusion:The results suggest that OSA in achondroplasia may further impair growth in these youngsters. Deficient sleep entrained secretion of GH is reversible by therapeutic tracheostomy.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goldstein, S., Wu, R., Rthorpy, M. et al. ACHONDROPLASIA AND OBSTRUCTIVE SLEEP APNEA: CORRECTION OF APNEA AND SLEEP ENTRAINED GROWTH HORMONE RELEASE BY TRACHEOSTOMY. Pediatr Res 18 (Suppl 4), 305 (1984). https://doi.org/10.1203/00006450-198404001-01271
Issue date:
DOI: https://doi.org/10.1203/00006450-198404001-01271
