Abstract
Previous work enables us to derive an equation for estimating creatinine clearance based on body length and serum creatinine in children and infants beyond the first month of life.
The purpose of the present study was to derive a simple equation for measuring creatinine clearance in appropriate for gestational age, preterm infants during the first month of life. To date, approximately one-half of the study has been completed. In 33 infants, 28-36 weeks' gestation, creatinine clearance was calculated from measurements of serum and urine (24 hour collection) creatinine. Post-natal age ranged from 4-30 days.
Gestational age, post-natal age, sex, Apgar Scores, weight, length, head circumference, serum creatinine, and aminoglycoside therapy, were subjected to multiple regression analysis. The ratio of body weight to serum creatinine had the best correlation with creatinine clearance (r =0.63; p<0.01). The regression equation is y=7.92033 + 0.00665 weight/serum creatinine (standard error of the estimate = 6.39). The predicted creatinine clearance differed from the observed creatinine clearance by [0.09-15.11 ml/min/1.73m2]. The addition of more patients will likely improve the ability to determine a stable coefficient for predicting creatinine clearance. Validation of the regression equation on a prospective sample will then be performed.
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Alkalay, A., Pomerance, J., Thangavel, M. et al. ESTIMATE OF CREATININE CLEARANCE IN PRETERM INFANTS DURING NG THE FIRST MONTH OF LIFE. Pediatr Res 18 (Suppl 4), 308 (1984). https://doi.org/10.1203/00006450-198404001-01293
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DOI: https://doi.org/10.1203/00006450-198404001-01293
