Abstract
This study examines the effects of 25 minutes of unilateral ischemia on RBF and on renal handling of PAH at high (H) and low (L) serum concentrations in the 40 minutes following reflow in anesthetized acutely saline expanded rabbits. RBF was monitored continuously by electromagnetic flow probes; serum (S) and urine (UV) were collected for clearance rates of PAH (Cpah) and inulin (Cin) from both the ischemic (I) and nonischemic (N) kidney. Infusion of PAH and inulin was begun after reflow. 40 minutes later kidneys were removed for determination of cortex-to-serum ratios of PAH (C/Spah) and inulin (C/Sin). Results are tabulated:
25 minutes of transient renal ischemia produced increased RBF in 11/11 animals in the immediate post ischemic period (mean pre ischemic RBF 33 ml/min, mean 0-10 minute post ischemic RBF 54 ml/min, p <.01). The increased RBF was accompanied by an increase in UV but not in Cin and Cpah. In this model, the post ischemic reduction of Cin and Cpah cannot be attributed to decreased RBF.
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Browning, M. INCREASED RENAL BLOOD FLOW (RBF) AFTER TRANSIENT RENAL ISCHEMIA. Pediatr Res 18 (Suppl 4), 358 (1984). https://doi.org/10.1203/00006450-198404001-01589
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DOI: https://doi.org/10.1203/00006450-198404001-01589
