HYPEROXIC LUNG INJURY: PUIMICNARY PROSTAGLANDIN (PG) INCREASES EASES PRECEDE MORPHOLOC

Abstract

To assess the role of PGs in the early development of hyperoxic lung injury, 11 adult rabbits with chronically implanted arterial and venous catheters were exposed to > 95% O₂ or air for 24 hours. At 24 hours, PaO₂ was 524 ± 41 (SD) and 92 ± 10 Torr in the hyperoxic and control rabbits. PG E₂, PG 6-keto F₁α and thromboxane (TX) B₂ levels (pg/ml) were measured by RIA in plasma and in bronchoalveolar lavage (BAL) supernatant. Protein (P) was measured in serum and BAL; BAL WBC and % PMN were also measured. Hyperoxic exposure for only 24 hours did not cause a significant increase in BAL P (Table, Mean ± SD) or any light or electron microscopic changes. However, BAL % PMN and the BAL:plasma PG 6-keto F₁α ratio both increased significantly. The increases in BAL:plasma PG E₂ and TX B₂ were not significant. In summary, increased PG 6-keto F₁α may be an early marker of hyperoxic lung injury. In addition to providing further support for a relationship between PGs and the development of hyperoxic lung injury, these results suggest a potential preventive role for PG inhibitors.

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