Abstract
Kraemer et al. (1982) reported on the altered theophylline clearance in 11 children during an Influenza B outbreak. In 5 children with R.S.V. infection we studied the theophylline pharmacokinetics (same dosage) during the acute illness and later at 5 weeks. None had cardiac or hepatic problems.
As the above table shows, all our patients had considerably higher serum theophylline levels and significant protraction of clearance during the acute illness. We conclude that the data highlight the importance of adjusting the dose and the monitoring of serum levels of theophylline in children with severe R.S.V. infection.
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Rao, M., Ames, M., Mitchell, M. et al. ALTERATION OF THEOPHYLLINE PHARMAKOKINETICS DUE TO R.S.V. INFECTION. Pediatr Res 18 (Suppl 4), 401 (1984). https://doi.org/10.1203/00006450-198404001-01851
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DOI: https://doi.org/10.1203/00006450-198404001-01851
