Abstract
Danazol has been reported to raise several plasma proteins. Danazol was given orally at 600 mg/day in 3 divided doses to 6 hemophiliacs for 8-14 weeks. Factor levels, APTT and other laboratory parameters were measured every 2 weeks. Five patients had classic hemophilia (1 mild-moderate, 3 severe, 1 with inhibitor) and 1 had Christmas disease. All patients showed a significant decrease an APTT beginning with the first measurement (2 weeks) and persisting till the drug was discontinued. However, a corresponding increase in the deficient factor activity could not be consistently demonstrated. Typical results for a severe classic hemophiliac are shown.
Despite the shortened APTT bleeding episodes continued in the severe hemophiliacs and the patient with Christmas disease. In 4 patients bleeding appeared to either increase in severity or change in pattern. In 2 patients bleeding did not respond to their usual factor infusions, but responded to discontinuation of danazol and further factor replacement. In 3 patients the drug was discontinued because of bleeding. These results differ from those recently reported. Increased fibrinolytic activity may be responsible for the altered bleeding.
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Garewal, H., Corrigan, J., Durie, B. et al. EFFECT OF DANAZOL ON APTT, COAGULANT FACTOR ACTIVITY AND BLEEDING IN HEMOPHILIA. Pediatr Res 18 (Suppl 4), 240 (1984). https://doi.org/10.1203/00006450-198404001-00883
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DOI: https://doi.org/10.1203/00006450-198404001-00883
