Abstract
PRP-DTP vaccine given to children at 18 mos. of age who have previously received this vaccine results in enhanced serum anti-PRP responses at 19 mos. of age, as measured by RIA. To assess the duration of elevated serum anti-PRP concentrations, antibody titers at 36-42 mos. of age in 31 prior recipients of PRP-DTP at 18 mos., 17 of whom had also received PRP-DTP in infancy, were compared with those at 19 mos. The mean GMTs (ug/ml) in the two groups did not change significantly in the interval.
In groups A and B, anti-PRP titer decreases of twofold or more occurred in 4/17 and 6/14 (p = 0.44), respectively. The frequency of anti-PRP concentration ≥ 0.15 and ≥ 1.0 ug/ml at 19 mos. and at 36-42 mos. in each group did not differ:
These findings indicate that anti-PRP titers in 3 to 3½ year old children immunized with PRP-DTP at 18 mos. of age reflect immunological responses at that age; and for those achieving high titers at 19 mos., subsequent doses of PRP may not be necessary to sustain protection.
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Peter, G., Stout, M., Lui, N. et al. 1149 PERSISTENCE OF ANTIBODY IN CHILDREN IMMUNIZED WITH HEMOPHILUS INFLUENZAE, B POLYSACCHARIDE (PRP) COMBINED WITH DTP VACCINE (PRP-DTP) AT 18 MONTHS OF AGE. Pediatr Res 19, 302 (1985). https://doi.org/10.1203/00006450-198504000-01179
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DOI: https://doi.org/10.1203/00006450-198504000-01179
