Abstract
TH influence F L maturation. However, it is not known if in vivo administration of TH enhance functional F L maturation. T4 (150 or 250μg/kg) or vehicle were injected IM to the rabbit doe on d 25 & 26. Functional & morphologic F L maturation was assessed on d 27 by pressure(P)-volume curve & histology. F plasma free T4 & T3 were measured by RIA. All data X+SEM (*P <0.05 vs con.) n=No. of does. UD=undetectable.
F wt & mortality were similar in all groups. Morphologic maturation was enhanced in T3-175 or 225 group only. In the T3-175 ♂ & ♀ F had more mature L.
Conclusion: Functional & morphologic acceleration of F L development from TH stimulation is concentration dependent & can be achieved transplacentally in ♂ & ♀ without affecting F growth or mortality.
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Devaskar, U., Church, J., Khafayan, E. et al. 1375 TRANSPLACENTAL STIMULATION OF FUNCTIONAL AND MORPHOLOGIC FETAL (F) LUNG (L) MATURATION: CONCENTRATION DEPENDENT EFFECT OF THYROID HORMONES (TH). Pediatr Res 19, 340 (1985). https://doi.org/10.1203/00006450-198504000-01399
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DOI: https://doi.org/10.1203/00006450-198504000-01399
