Abstract
In order to test the hypothesis that treatment with IV indomethacin to close the ductus arteriosus has beneficial effects on lung function in preterm infants with HMD, 9 preterm infants requiring ventilator support on day 3(mean birthweight 1186±276 gm, gestational age 29±3 wk)were given 0.2mg/kg of indomethacin IV on day 3-4 of life. They were compared with 16 concurrent random controls with HMD on ventilators on day 3(birthweight 1063±282 g, gestational age 28±2 wk) who did not receive indomethacin.
The observed differences between treatment and control groups on day 3, and within groups (day 3 vs. day 5) are not statistically significant (p >.05). These data suggest that although IV indomethacin may significantly alter the patency of the ductus arteriosus, administration of this drug on day 3-4 of life is not associated with a significant improvement in preterm infants with HMD.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Krauss, A., Fatica, N., Lewis, B. et al. 1431 PULMONARY FUNCTION AFTER IV INDOMETHACIN IN PRETERM INFANTS. Pediatr Res 19, 349 (1985). https://doi.org/10.1203/00006450-198504000-01455
Issue date:
DOI: https://doi.org/10.1203/00006450-198504000-01455
