Abstract
In a prospective study of NACMV infection in a 35 bed neonatal ICU initial results suggested an association between the transfusion of CMV-IgM(+) blood products (BP) and NACMV. During a 14 month period 165 seropositive (S+) neonates and 386 seronegative (S-) neonates were monitored for CMV infection by weekly viral culture (VC). VC(+) infections occurred in 13/165 S+ neonates and 7/386 S- neonates. All 7 S- neonates with NACMV received blood from one or more S+ donors and one or more CMV-IgM(+) donors (X2=7.94 p<0.005). No CMV infections were detected in 79 S- infants who received exclusively S- blood, or in 76 S- infants who received CMV ELISA(+), IFA-IgM(-) blood. During the next 9 months we prospectively evaluated the degree to which transfusion related CMV can be reduced by the exclusive use of CMV-IgM(-) blood. Eighty-one S+ and 117 S- nsonates have been followed. Three of these 81 S+ babies and none of 117 S- neonates, including 64 who were transfused with IgM(-) blood became VC(+). The incidence of CMV infections in S+ neonates (16/246) was approximately 4 fold greater than in S- neonates (7/503). We conclude that the incidence of NACMV in S- neonates can be reduced by interdicting CMV S+ BP. While screening with an IgM-IFA was effective in this study, other assays which detect total antibody are more readily performed and should be considered pending further evaluation of alternative assays for the detection of infectious BP.
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Lamberson, H., McMillan, J., Weiner, L. et al. 1434 NURSERY ACQUIRED CMV (NACMV) INFECTION IN TRANSFUSED NEONATES. Pediatr Res 19, 349 (1985). https://doi.org/10.1203/00006450-198504000-01458
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DOI: https://doi.org/10.1203/00006450-198504000-01458
