1509 LONG TERM FOLLOW-UP OF INFANTS WITH BRONCHOPULMONARY DYSPLASIA (BPD)

Abstract

179 infants with BPD and 112 matched controls were compared in terms of perinatal factors and long-term outcome (1-8 yrs). Perinatal factors significantly (p < .001) more common in cases were, gestational age ≤29 weeks, hyaline membrane disease, episodes of hypoxia and acidosis, interstitial emphysema, pneumothorax, patent ductus arteriosus, long duration of assisted ventilation, episodes of endotracheal tube plugging, atelectasis, post extubation airway obstruction, ≥ 10 blood transfusions and the need for parenteral nutrition. 20 cases and 1 control (p<.001) died after discharge from hospital. Significant differences in outcome (p < .002) included increased frequency of lower respiratory illness, rehospitalization during the first year of life, abnormal physical findings on chest exam, growth deficits and the occurrence of retrolental fibroplasia. Neurodevelopmental outcomes, hearing and speech disorders, were more frequent in cases, but differences were not significant. 24/99 (24.2%) of cases and 7/49 (14.3%) of controls had cognitive delays, 28/141 (19.9%) or cases and 8/66 (12.1%) of controls had abnormalities on the Test of Gross Motor and reflex development, and 15/141 (10.6%) of cases and 5/66 (7.6%) of controls had cerebral palsy. Infants with BPD had higher post discharge mortality and morbidity rates in some areas, but differences in neurodevelopmental outcome were not significantly different in the two groups.

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