Abstract
3 week old female Spraque Dawley rats were divided into N and CRF groups. CRF was created by heminephrectomy followed in 7 days by contralateral nephrectomy. Each group was subdivided into 3 diet groups - 6, 14 and 24 percent protein. All diets were isocaloric and contained equivalent amounts of Na, K, Cl, Ca and phosphate. Wt and Ht were measured weekly for 9 wks. (12 wks. of age). *P<.05 compared to 24%.
Animals on 6% diet were statistically significantly smaller than 24% diet (usual protein content of rat chow) and 14% diet, both under N or CRF conditions. Under N conditions 14% animals gained more wt then 24%; under CRF the same tendency was seen. Wt and Ht were most severely effected by the combination of CRF and protein restrictions (6% diet). We conclude that:
(1) Severe protein restriction limits growth even further in the young animal with CRF. (2) Mild protein restriction without calorie restriction may be beneficial for growth in CRF.
(3) Dietory manipulation in the young animal must be different than the adult animal to test the benefit of protein restriction as treatment of CRF.
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Friedman, A., Pltyer, R. 1579 EFFECT OF PROTEIN RESTRICTION ON GROWTH IN NORMAL (N) AND CHRONIC RENAL FAILURE (CRF) RATS. Pediatr Res 19, 377 (1985). https://doi.org/10.1203/00006450-198504000-01621
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DOI: https://doi.org/10.1203/00006450-198504000-01621
