Abstract
Plasma Pi in early life is high and renal Pi excretion low relative to that in adults. Renal tubular Pi transport kinetics and membrane LF was investigated in apical membrane vesicles (BBMV) in 6 fetal (F) lambs and pregnant ewes (E).
Results:
KmPi was similar in BBMV in the F and E but Vmax Pi was greater in F. Alkaline phosphatase enrichment, lipid saturation index and [cholesterol/phospholipid], [sphingomyelin/phosphatidylcholine] ratios were not different, however, protein/lipid ratios was higher in E. The results demonstrate greater renal tubular Pi transport capacity in F compared to E and increased VmaxPi in F is due, in part, to greater membrane LF. Relative increased VmaxPi in F may be due to difference in carrier function rather than to an increase in carrier concentration. This may involve more rapid cycling of Pi carrier from lumen to cytoplasmic surfaces in F.
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Moore, E., Rufer, L., Brasitus, T. et al. 1621 APICAL MEMBRANE LIPID FLUIDITY (LF) INFLUENCES PHOSPHATE (Pi) TRANSPORT IN FETAL KIDNEY. Pediatr Res 19, 381 (1985). https://doi.org/10.1203/00006450-198504000-01645
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DOI: https://doi.org/10.1203/00006450-198504000-01645
