1710 RAPID CORRECTION OF CHRONIC HYPONATREMIA (CHR HYPONa⁺) ELEVATES DEPRESSED BRAIN (Br) AMINO ACID LEVELS [AA]) IN MICE: POSSIBLE RELATION TO CENTRAL PONTINE MYELINOLYSIS (CPM)

Abstract

Effects of Chr Hypo-Na⁺ or rapid correction of Chr Hypo-Na⁺ on Br metabolism are unknown. Acute Hypo-Na⁺ (4h) reduced Br [AA] in mice (J Neurochem 24:953 (1975)). If similar findings occur in Chr Hypo-Na⁺, elevation of plasma (Pl) [Na⁺] might elevate Br [AA] (J Neurochem 40:240 (1983)). To test the hypothesis 20-d-old mice were made Hypo-Na⁺ (4-d Pitressin + 2.5% dextrose); then treated with 1 M and 0.9% NaCl for 9h. Pl [Na⁺] (meq/l) and Br [AA] (mmol/kg) (mean ÷ SE) are given below.

Chr Hypo-Na⁺ decreased Br [AA] 23% to 74% (P<0.005). Rapid elevation of PL [Na⁺] increased Br glutamate and aspartate levels above normal (14% and 44%, respectively (resp.), P≤0.014); glycine and taurine levels were still reduced (27% and 65%, resp., P<0.006). Osmotic disequilibrium or injury to endothelial cells could produce Br edema. Increased levels of glutamate and aspartate (neuroexcitatory) and decreased levels of taurine and glycine (neuroinhibitory) could relate to the hyperactivity and/or seizures and the neuropathology seen in experimental CPM.

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