Abstract
In fetal guinea pigs oligohydramnios (OH) causes lung hypoplasia which is more severe the earlier the onset and the longer the duration of OH (Ped. Res. 18:336A, 1984). We have quantitated the structural alterations in the lungs of fetal guinea pigs subjected to OH from 45 to 50 days gestation (term 67 days). OH fetuses (n=5) compared to littermate controls (n=4) have:
Even a brief period of OH during the late canalicular-early saccular phases of lung development is sufficient to markedly reduce fetal lung growth and to cause profound structural changes. The disproportionate effect of OH on elastic tissue may be related to the fact that this tissue first appears in the parenchyma of the fetal guinea pig lung on day 45; this adverse effect might impede the ability of the lung to recover and could have long term sequelae.
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Collins, M., Moessinger, A., Kleinerman, J. et al. 1746 MORPHOMETRY OF OLIGOHYDRAMNIOS-INDUCED FETAL LUNG HYPOPLASIA. Pediatr Res 19, 401 (1985). https://doi.org/10.1203/00006450-198504000-01764
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DOI: https://doi.org/10.1203/00006450-198504000-01764
