Abstract
To evaluate clinical and hormonal response to intranasal Gn-RH, 12 cryptorchidism boys, 10 unilateral (UC) and 2 bilateral (BC) were studied. All of them were treated with 200 μg of Gn-RH sprayed 6 times daily during 4 weeks. Serum samples were collected during intranasal Gn-RH stimulation test. The tests were performed after the first inhalation on the first and last day of treatment. Levels of LH, FSH, PRL and testosterone were measured by RIA and LH biological activity by bioassay (bio LH). In 4 patients (Group I) 3 with UC and 1 with BC, complete descent of the testes occurred. Other 4 patients (Group II) 3 with UC and 1 with BC needed an additional 4 weeks of treatment to complete descent. In the remaining 4 (UC) patients (Group III) testicular descent occurred outside the inquinal canal. Basal LH and FSH levels (RIA) were similar at the beginning and at the end of treatment and the initial response did not differ from group to group. FSH response showed a significant decrease at the end of treatment. Testicular descent occurred in 50% of patients being a good correlation between LH biological activity and response to treatment. This would suggest that a major degree of hypophyseal maturity would be necessary to release bio LH improving therapeutical results.
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Gottlieb, S., Domené, H., Solano, A. et al. 162 EFFECT OF INTRANASAL Gn-RH IN PREPUBERTAL CRYPTORCHIDISM. Pediatr Res 19, 630 (1985). https://doi.org/10.1203/00006450-198506000-00182
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DOI: https://doi.org/10.1203/00006450-198506000-00182
