Abstract
Radioimmunoassayable urinary gonodotropins and urinary 17 ketosteroid (KS) levels have been determined in 223 24 hour urine samples from 65 patients with 21-hydroxylase deficiency congenital adrenal hyperplasia. Results have been categorized by sex and, based on chronologic age, skeletal age and physical findings as prepubertal (Pre), pubertal (Pub) and postpubertal (Post). LH and FSH levels were divided into 2 groups based on KS, elevated (↑) or normal (Nl) for treatment adequacy.
LH levels are significantly lower *(p<0.03) when KS levels are inappropriately elevated for age and stage of development in pubertal males and females. This effect is reversible with a significant rise of LH levels (18.1±13.0 to 64.2±34.2, <p 0.001) when KS were suppressed in 10 pubertal subjects.
These data suggest that the elevated adrenal androgens in inadequately treated adrenal hyperplasia suppress developing pubertal hypothalamic-pituitary gonadotropin secretion.
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Lee, P. 461 SUPPRESSED URINARY LH LEVELS IN INADEQUATELY TREATED PUBERTAL PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA. Pediatr Res 19, 187 (1985). https://doi.org/10.1203/00006450-198504000-00491
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DOI: https://doi.org/10.1203/00006450-198504000-00491
