Abstract
78 children with retardation of growth and/or sexual maturation had pituitary dynamic studies, nocturnal growth hormone (GH) sampling and CT scan for suspected GH deficiency. In 19/78, PESS was diagnosed by high resolution CT scanning (5 girls and 14 boys). Bone age was delayed, but sella turcica was normal in size and shape in all PESS patients. Ten of the patients had normal pituitary studies. Two of the patients (I & II) had panhypopituitarism (GH, TSH & ACTH deficiencies). In 4 patients (III–VI), peak GH was <7.0 ng/ml. In 3 others (VII–IX), peak GH was 8.1–9.8 ng/ml. One patient (I) remained hyperprolactinemic even after thyroid replacement.
Conclusions: 1. PESS is not uncommon in growth retarded children; 2. It may be the cause of “idiopathic hypopituitarism”.
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Radfar, N., Rajj, M., Dastur, K. et al. 484 HYPOPITUITARISM IH CHILDREN WITH “PRIMARY EMPTY SELLA SYNDROME (PESS)”. Pediatr Res 19, 191 (1985). https://doi.org/10.1203/00006450-198504000-00514
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DOI: https://doi.org/10.1203/00006450-198504000-00514
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