Abstract
The shape of the curve of plasma-64Cu as function of time after an i.v. dose of 0.5 mg of 64Cu yields information about the Cu-status of the patient. The drop in 64Cu during the first hours post dose is less steep when the exchangeable, mobile Cu in the body is high (curve 3 versus 2; curve 4 versus 5). The increase plasma-64Cu after t=5 h post dose is due to incorporation of in the plasma protein ceruloplasmin: lower liver-Cu results in a higher incorporation of 64Cu (curve 1 versus 2). Application of the test to Wilson's disease (especially for early recognition) and some other - in part unexplained metabolic disorders affecting the Cu-metabolism - will be mentioned. A protocol which leads to acceptable exposures to 64Cu will be given.
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Van Den Hamer, C., Hoogenraad, T. 86 64COPPER-LOADING TEST AS INDICATOR OF ELEVATED LIVER-COPPER, E.G., IN WILSON'S DISEASE. Pediatr Res 20, 1048 (1986). https://doi.org/10.1203/00006450-198610000-00140
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DOI: https://doi.org/10.1203/00006450-198610000-00140
