Abstract
The aim of this study was to determine the incidence and predictive factors of PDA in a cohort of 1307 infants of less than 32 weeks gestation and/or birth weight below 1500 gms, representing 96% of these infants born within 1 year in the Netherlands.
Symptomatic PDA was diagnosed (by clinical, radiological and ultrasound criteria) in 251 infants (19.2%).
Using stepwise logistic regression analysis, it appeared that, among 9 perinatal factors tested, gestational age was the most predictive factor for both the occurrence and severity of PDA, followed by idiopathic respiratory distress syndrome.
Furthermore, we found that infants with PDA had significantly more apnea and developed more bronchopulmonary dysplasia than infants without PDA.
We conclude that onset and severity of PDA are especially determined by gestational age.
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van de Bor, M., Pauline Verloove-Vanhorick, S., Brand, R. et al. Incidence and prediction of patent ductus arteriosus (PDA) in a cohort of 1307 preterm infants. Pediatr Res 22, 225 (1987). https://doi.org/10.1203/00006450-198708000-00073
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DOI: https://doi.org/10.1203/00006450-198708000-00073
