Abstract
A 9 yo black male with acute leukemia showed a unique chromosome abnormality and unusual phenotypic and genotypic features. He presented with fever, lethargy, weight loss, and cervical adenitis without organomegaly or enlarged thymus. The Hgb was 4.6 gm/dl, platelets 50,000/dl, and WBC 25,000/dl, 96% blasts of moderate size with scanty-cytoplasm and indistinct nucleoli. Some were larger with more cytoplasm and had nucleoli. The marrow blasts were larger, had large nuclei, prominent nucleoli, a moderate amount of bascphilic cytoplasm and no auer rods. They were 42% Sudan black and 20% peroxidase positive, FAB-MI. Immunophenotyping showed T-cell markers (Leu 1,9)-88%, B-cell markers (Leu 12)-44%, myeloid markers (My 9)-5%, Dr (Ia)-0%, and TdT-29%. The cells were negative for surface and cytoplasmic immunoglobulin (Ig). Karyotyping showed 46,XY,t(1; 10) (p32; p13), in all cells analyzed. Southern blots showed Ig heavy chain and T-cell receptor β-chain gene rearrangement. In summary, the patient had acute leukemia with L1 or L2-M1 peripheral blasts. The marrow cells were FAB L2-M1 and histochemically were Ml. Immunophenotyping showed features of B-cells (leu12) and T-cells (leul, leu9). The Ig heavy chain and T-receptor β-chain genes were rearranged. All cells had a new translocation, t(1:10) (P32:p13).
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Ducore, J., Wasserman, R. & Schneider, N. ACUTE MIXED LINEAGE LEUKEMIA: UNIQUE KARYOTYPIC, GENOTYPIC, AND PHENOTYPIC FEATURES. Pediatr Res 21 (Suppl 4), 298 (1987). https://doi.org/10.1203/00006450-198704010-00785
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DOI: https://doi.org/10.1203/00006450-198704010-00785
