Abstract
The hematologic manifestations of 100 pediatric patients with AIDS/ARC were reviewed. Acute or chronic anemia was present in 94% of all patients. Two patients had autoimmune hemolytic anemia and 1 patient had an aplastic anemia. A positive Coombs test was detected in 40% of all patients. Leukopenia and neutropenia occurred in 50% and 40% of patients respectively. Antineutrophil antibodies were detected in 2 patients. Ten of 13 children developed neutropenia on Bactrim. Forty percent of all children were lymphopenic. Monocytosis and eosinophilia occurred in 66% and 40% of patients respectively. Thrombocytopenia was seen in 33% and of these 25% developed a persistent thrombocytopenia. Platelet antibodies were detected in 10 of 11 patients. Pancytopenia occurred in 20% of children with opportunistic infection (O.I.). Acquired Von Willebrands disease and autoantibodies to Factors X, XI and XII were seen in 2 individuals. Peripheral smears revealed ovalocytes, microcytosis, hypochromia and atypical lymphocytes. Bone marrow examination showed hypercellularity, myeloid hyperplasia and increased plasma cells and lymphocytes. Decreased erythropoeisis, dysmyelopoeisis, dyserythropoeisis and megaloblastic changes were occasionally seen. Bone marrow cultures were positive for mycobacterium avium intra cellulare (4), Candida (2) and CMV (1) in a total of 7 patients.
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Ellaurie, M., Shah, K., Bernstein, L. et al. HEMATOLOGIC MANIFESTATIONS OF PEDIATRIC AIDS. Pediatr Res 21 (Suppl 4), 298 (1987). https://doi.org/10.1203/00006450-198704010-00786
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DOI: https://doi.org/10.1203/00006450-198704010-00786
