Abstract
To compare its effectiveness in stimulating growth-hormone (GH) release, GH-RH (1-44) NH2 was given intravenously (80 mcg; n=16), subcutaneously (2.1; 4.2, 8.4; 12 b; 168 and 21 mcg/kg; n=16) and intranasally (1.4, 3.6; 7; 14.21 and 28 mcg/kg; n=16) to normal male volunteers.
GH stimulation occured in a dose-responsive manner after SC and after IN routes of administration. Although the degree of GH stimulation terms of GH peak and GH integrated concentration, was variable among subjects, the greatest amount of stimulation occured with the highest doses. If maximal observed concentration of GH is used as an indicator of responsiveness to the various doses and routes of administration, approximately a 15 fold higher SC dose and a 25 fold higher IN dose were required to stimulate a comparable amount of GH secretion as compared with IV administration.
Stimulation of GH secretion occured within 30 minutes of IV and SC administration and within 45 minutes of IN 6R-RH(1-44)NH2 administration.
It is concluded that optimisation of IN administration of GH-RH(1-44) NH2 is necessary before using it for long-term therapy in children with GH deficiency.
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Colle, M., Frangin, G., Auzerie, J. et al. THE EFFECTS OF INTRAVENOUS(IV), SUBCUTANEOUS (SC) AND INTRANASAL (IN) ADMINISTRATION OF 6H-RH(1–44)MH2 ON GROWTH-HORMONE SECRETION IN NORMAL MEN: DOSE-RESPONSE RELATIONSHIPS. Pediatr Res 23, 120 (1988). https://doi.org/10.1203/00006450-198801000-00115
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DOI: https://doi.org/10.1203/00006450-198801000-00115
