Abstract
T 3-4 weeks after an i.m. dose of T, many of our HH patients deny a decline in sexuality so soon. To evaluate the effects of T replacement, 9 patients with HH, 18-30 years of age, were studied. Following an i.m. dose of 250 ng T propionate/enanthate they were studied at the 2nd, 4th, 6th and 8 weeks, then received a placebo dose and were reevaluated 1 week later. At each overnight study, they underwent a set of penile tumescence (PT) recordings during a pornographic film and slides, self-induced erotic fantasy and nocturnal PT, as well as self-report of a 10-point questionnaire. Results were compared to those of 10 volunteers. Serum T declined to subnormal levels by the 4th week. On the self-report, sexual drive and fantasies were comparable to controls, but rating of sexual relations, erection time and ejaculations were significantly lower (p<0.01). Self-rating of erection strength showed a gradual decline (p<0.05) and became subnormal by the 8th week. Nocturnal PT and erotic-response PT were normal throughout the 9 weeks of the study and did not drop to subnormal values. It is concluded that the stimulatory effects of T replacement in HH involve mainly libido factors and extend beyond the period of normal serum T. Therapy must be evaluated by these criteria and can be administered bimonthly.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eyal, A., Ish-Shalom, S. & Hochberg, Z. EFFECTS OF TESTOSTERONE (T) REPLACEMENT ON MALE SEXUALITY IN HYPOGONADOTROPIC HYPOGONADISM (HH). Pediatr Res 23, 132 (1988). https://doi.org/10.1203/00006450-198801000-00184
Issue date:
DOI: https://doi.org/10.1203/00006450-198801000-00184
