Abstract
CT deficiency has been reported in children and adolescents with CH;but whether it is also deficient in CH patients during infancy has not been investigated. Plasma extraction of CT has much improved the sensitivity and specificity of CT radioimmunoassays for the measurement of the monomeric CT form, the active form of this hypocalcemic hormone. To further analyze CT secretion in early infancy, we measured CT and Calcium (Ca) values in 1) normal infants aged 0-2 yrs (gr. NL-1, n=39) and 2-5 yrs (gr. NL-2, n=12) and 2) CH infants aged 0-2 yrs (gr. CH-1, n=6) and 2-5 yrs (gr. CH-2, n=6)
Results are shown in the table (Mean ± SEM) : (xx p<0,01 as compared to groups NL)
The data show that CT values 1) decrease during the first years of life in both normal and CH patients, and 2) are lower in CH than in normal subjects.
In conclusion: 1) low but detectable values of CT are present in CH patients, indicating that functional calcitonin secreting cells do exist in these patients; 2) the low CT levels in infants with CH as compared with normal subjects suggest that CT deficiency could have an important pathogenic role in the hypercalcemia occasionally observed in CH patients during the neonatal period.
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Chanoine, J., Body, J., Van Vliet, G. et al. 23 MONOMERIC CALCITONIN (CT) DEFICIENCY IN PATIENTS WITH CONGENITAL NON GOITROUS HYPOTHYROIDISM (CH) DURING EARLY INFANCY. Pediatr Res 24, 521 (1988). https://doi.org/10.1203/00006450-198810000-00044
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DOI: https://doi.org/10.1203/00006450-198810000-00044
