Abstract
Plasma HX concentration was monitored in four preterm babies with severe RDS who were treated with natural surfactant (G.A. 28-30 weeks, B.W. 1115-1325 g). FiO2 before surfactant application ranged between .9-1.0. There was a 262% increase in HX concentration 15 min after surfactant administration (p<.05). After 60 min the HX level reached pretreatment levels in all but one baby. There was no changes in HX concentration in control babies.
These data demonstrate a significant washing out of HX after surfactant application. Whether or not this comes from the lungs is not known. Since HX is an oxygen radical generator it is speculated whether this phenomenon plays a role in the clinical situation.
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Saugstad, D., Gloppestad, K., Tubman, T. et al. WASHING OUT OF HYPOXANTHINE (HX) IN PRETERM BABIES WITH RDS TREATED WITH NATURAL SURFACTANT (CUROSURF). Pediatr Res 26, 511 (1989). https://doi.org/10.1203/00006450-198911000-00073
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DOI: https://doi.org/10.1203/00006450-198911000-00073
