Abstract
We evaluated the “in vivo” activation of the hemostasis in 14 children (aged 4 to 13) with Nephrotic Syndrome (NS) at onset, determinating the blood platelet count (PLT, × 109/l), B-thromboglobulin (B-TG, ng/ml), platelet factor 4 (PF4, ng/ml), factor I (mg/dl), and the inhibitors (AT-III -mg/dl- and PC:Ag -%-), and D-dimers (ng/ml).
AT-III shows a positive correlation (r = 0.80; p < 0.001) with serum albumin; PC shows a negative correlation with serum albumin (r - 0.40;p < 0.05) and a positive one with urinary albumin (r = 0.40; p < 0.05). Thrombotic risk in Nephrotic Syndrome at onset does not seem to be caused by an inhibitor reduction For the increased PC levels; changes oF platelet number and functions and of fibrinogen level assume more importance. (supported by a grant from MPI - 40%)
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Schettini, F., De Mattia, D., Penza, R. et al. THROMBOEMBOLIC RISK IN CHILDREN WITH NEPHROTIC SYNDROME. Pediatr Res 26, 525 (1989). https://doi.org/10.1203/00006450-198911000-00157
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DOI: https://doi.org/10.1203/00006450-198911000-00157
