Abstract
The effect of cyclooxygenase inhibition on ChBF and RBF during hypercarbia was investigated in tracheotomized, paralyzed and mechanically ventilated newborn piglets. The animals were assigned to a placebo group (n=5) or an indomethacin (Indom) group (n=6). The results were (flow expressed as ml/min/100g tissue X ± SEM):
*p<0.01 (Room air vs post treat CO2). **p<0.05 ( Basal room air vs post treat Room air), #p<0.01 (between groups).
Indomethacin reduced RBF and eliminated the RBF increase in response to hypercarbia. The effect on ChBF was similar but less marked. The results suggest that the changes in RBF and ChBF in response to hypercarbia are mediated by arachidonic acid metabolites and that these metabolites are involved in maintaining normal occular vascular tone. These findings may have implications regarding the use of indomethacin in children with respiratory failure and hypercarbia.
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Stiris, T., Suguihara, C., Hehre, D. et al. 87 THE EFFECT OF CYCLOOXYGENASE INHIBITION ON RETINAL (RBF) AND CHOROIDAL (ChBF) BLOOD DURING HYPERCARBIA IN NEWBORN PIGLETS. Pediatr Res 28, 290 (1990). https://doi.org/10.1203/00006450-199009000-00111
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DOI: https://doi.org/10.1203/00006450-199009000-00111
