Abstract
The effects of 4 feeding regimes on the development of atopic disease and sensitization against cow's milk proteins were compared in a prospective study of 522 children with a 2 year follow-up. Healthy newborns were assigned to 4 groups: (Br)Exclusively breast fed;(Br+HA)Breastfed and hypoallergenic formula;(Br+CM)Breastfed and cow's milk;(CM)Cow's milk. Serological investigations included IgG-,IgA- and IgE-antibodies against 4 CM-proteins interpreted by a geometrical mean titer (gmt)(Bürgin-Wolff, Eur J Ped 1980:133).
Results: The percentage of children developing clinical signs of atopic disease is given in the table.
Low risk Risk:other parental allergy Risk parental AD
Gmt values were highest in groups (Br+CM) and (CM) irrespective the parental allergy- and AD-status. CM-antibodies in breastmilk were not protective. Children of parents with AD developed allergy most frequently. Feeding HA formula is only of limited benefit.
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Keller, K., Bürgin-Wolff, A., Wirth, S. et al. 12 ALLERGY PREVENTION IN CHILDREN OF PARENTS WITH ATOPIC DERMATITIS (AD). Pediatr Res 30, 630 (1991). https://doi.org/10.1203/00006450-199112000-00042
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DOI: https://doi.org/10.1203/00006450-199112000-00042
