Abstract
To test the effects of resuscitation with 21% or 100% O2 on cerebral blood flow (CBF), hypoxemia was induced in 14 newborn pigs (2-5 days) by ventilation with 8% O2 in nitrogen. When base excess reached -20 mmol/L, they were randomly resuscitated with either 21% O2 (n = 6) or 100% O2 (n=8) for 25 min followed by 21% O2 in both groups. Blood flow was measured in brainstem (BS), cerebellum (CBL) and cerebrum (CBR) with a radioactive microsphere method.
Mean duration of hypoxemia was 59 min in both groups. Flow values were (ml/lOOg/min, mean±SD):
CBF was significantly increased in both groups in all areas after 5 and 20 min of reoxygenation.
Conclusion: We could not demonstrate any significant differences in regional CBF between two groups of hypoxic newborn pigs reoxygenated with 21% or 100% O2.
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Rootwelt, T., Odden, JP., Hall, C. et al. CEREBRAL BLOOD FLOW DURING HYPOXEMIA AND REOXYGENATION WITH 21% OR 100% O2 IN NEWBORN PIGS. Pediatr Res 32, 631 (1992). https://doi.org/10.1203/00006450-199211000-00157
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DOI: https://doi.org/10.1203/00006450-199211000-00157
