Abstract
3O prepubertal (26 boys, 4 girls) isolated growth hormone (GH) deficient children were studied before and after one year treatment (0,5 U/kg/week Genotropin, Norditropin and Saizen). 12 of them (11 boys, 1 girl) were analysed after two years on GH therapy too.
Measurement of metaphyseal band (MB) was completed by Protomix LTD medical image processing and archiving microprosessor based system. After the first year of treatment the average (x±SD) MB grew from O,92±0,46 to 1,71±0,63 mm; xIGF-I:63,4±57,7 to 215,5±208,5 ng/ml; xHV:2,0±1,4 to 8,5±4,0 cm. In the second year the average MB diminished:1,43±0,46 mm; xIGF-I changed to 214,1±225,0 ng/ml; xHV:10,2±3,9 to 7,2±2,6 cm (p<0,001). Comparing the change in HV, MB and plasma IGF-I levels, correlation was found only in the second year of treatment between BM and IGF-I levels.
Conclusions:1. The MB, the HV, plasma IGF-I significantly grew during the first year of treatment.
2. In the change of MB the role of IGF-I could be suspected: a., both parameters significantly grew during the first year; b., in the second year on GH treatment both the HV and MB diminished, simultaneously with the change in IGF-I levels.
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Tar, A., Szécsényi-Nagy, I. & Péter, F. ANALYSIS OF THE RADIAL METAPHYSEAL BAND, HEIGHT VELOCITY AND IGF-I LEVELS IN ISOLATED GROWTH HORMONE DEFICIENT PATIENTS. Pediatr Res 33 (Suppl 5), S59 (1993). https://doi.org/10.1203/00006450-199305001-00338
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DOI: https://doi.org/10.1203/00006450-199305001-00338
