Abstract
The lipolytic effect of growth hormone (GH) was investigated in adipocytes obtained during elective surgery from otherwise healthy adults, 18-40 years old. No lipolytic or antilipolytic effect of GH was found when the cells were incubated with GH alone during 30min-6h. When the cells were preincubated with GH during 3h, the lipolytic sensitivity for isoprenaline increased markedly without any change in maximal lipolysis. However, a full effect was only obtained if GH was also present during the incubation with isoprenaline. The effect of GH was reduced, by cycloheximide. GH did not alter DB-CAMP, enprophylline, or forskoline-induced lipolysis in human fat cells. In conclusion, GH had no direct lipolytic effect on human fat cells but GH markedly increased the catechoiamine sensitivity by a mechanism which involves protein synthesis. The site of the GH effeet seems to be in the β-adreno-ceptors or in the GH coupling protein.
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Marcus, C., Bolme, P., Micha-Johansson, G. et al. GROWTH HORMONE INCREASES THE LIPOLYTIC SENSITIVITY FOR CATECHOLAMINES IN HUMAN ADIPOCYTES. Pediatr Res 33 (Suppl 5), S68 (1993). https://doi.org/10.1203/00006450-199305001-00389
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DOI: https://doi.org/10.1203/00006450-199305001-00389
