Abstract
An open pilot trial of low dose cyclosporine was initiated in first degree relatives of type I diabetic children with the following criteria: age<12 years, HLA haploidentical or identical to the diabetic proband, ICA≥20 JDF units, first phase insulin response to glucose (1+3 minutes) repeatedly <40μU/ml, glucose intolerance according to NDDG criteria.
We conclude that cyciosporine can restore insulin secretion and glucose tolerance in preclinical diabetes. Failure in patient V.W. might be due to a long period of low insulin secretion prior to immunosuppression. The efficacy of this approach should be tested in a larger number of patients.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carel, J., Bougnères, P. PRELIMINARY RESULTS OF A TRIAL OF LOW DOSE CYCLOSPORINE IN PRECLINICAL TYPE I DIABETES. Pediatr Res 33 (Suppl 5), S74 (1993). https://doi.org/10.1203/00006450-199305001-00427
Issue date:
DOI: https://doi.org/10.1203/00006450-199305001-00427
