Abstract
Because of delayed gluconeogenesis and small amounts of stored glycogen, hypoglycaemia often occurs among growth-retarded newborns. With microdialysis(MD), measurements of small molecules in situ can be determined. The MD probe is a double lumen plastic cannula with a tubular semipermeable membrane perfused with Ringer. With MD probes placed in the abdominal subcutaneous tissue five small-for-gestational-age and two appropiate-for-age infants were monitored immediately after birth. The infants showed marked sample to sample variations in dialysate glucose not seen among children, which may be due to poor hormonal regulation. Good correlation was seen between levels in blood and dialysate glucose(r=0.93). Dramatic variations in lactate (0.5-5.9 mM/L) were seen without obvious clinical correlation. The levels were higher than those reported in blood and may serve as an alternative energy source. Glycerol levels showed no correlation with the other investigated metabolites.
In conclusion: single blood glucose levels probably mirror glucose homeostasis of the neonate poorly. MD seems to be a valuable method for continuously measuring interstitial glucose levels in neonates.
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Horal, M., Ungerstedt, U. & Marcus, C. 98 METABOLIC ADAPTATION AMONG SGA-INFANTS DETERMINED WITH MICRODIALYSIS. Pediatr Res 36, 19 (1994). https://doi.org/10.1203/00006450-199407000-00098
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DOI: https://doi.org/10.1203/00006450-199407000-00098
