Abstract
Recently, we observed an outbreak of measles among highschool children in The Netherlands, where 23 out of 949 children developed clinical measles. The virus was isolated, which, on the basis of nucleotide sequence analysis, appeared to be closely related to the wild-type MV strains that had circulated in Europe and the USA in 1989. Blood samples were collected from 10 cases with clinical measles and from 37 children who exhibited only part of the symptoms (n = 33) or were clinically healthy (n=4). The simultaneous evaluation of antibody and T cell mediated measles virus (MV) specific immune responses allowed a more accurate identification of individuals with MV infection than the evaluation of specific antibody responses atone (IgM or IgG or both). On basis of the presence of MV specific IgA and of CD8 + CTL, it was concluded that 29 of the 47 children investigated had recently been infected with MV. Of these 29 children, 24 had a documented history of live MV vaccination. The replication of MV in individuals vaccinated with live attenuated measles vaccine may thus have implications for future MV eradication strategies.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Van Binnendijk, R., Poelen, M., Van Loon, T. et al. 332 MEASLES IN VACCINATED HIGHSCHOOLCHILDREN AS EVIDENCED BY SPECIFIC CYTOTOXIC T CELL (CTL) AND IgA RESPONSES. Pediatr Res 36, 58 (1994). https://doi.org/10.1203/00006450-199407000-00332
Issue date:
DOI: https://doi.org/10.1203/00006450-199407000-00332
