LUNG FUNCTION AT SCHOOL-AGE IN CHILDREN PARTICIPATING IN A RANDOMIZED SURFACTANT TRIAL (ALVEOFACT®) FOR TREATMENT OF RDS. 1938

OBJECTIVE: To determine long-term outcome of pulmonary function in preterm infants treated with bovine surfactant for respiratory distress syndrome, we investigated lung function in these patients at school-age.

PATIENTS AND METHODS: 40/52 surviving infants taking part in a randomized multi-center trial for the treatment of RDS were investigated. Initial treatment consisted of either up to 200 mg/kg of a bovine surfactant(Alveofact®) or air placebo. 22 had received surfactant (S), 18 were placebo-treated (P). Mean (SD) gestational age had been 28.1 (1.5) and 27.7(1.3) weeks. Bronchopulmonary dysplasia had been diagnosed in 2 surfactant-treated patients as compared to 9 in the control group. At follow-up mean (SD) age was 6.63 (0.18) and 6.55 (0.23) years.

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