PURIFIED SERUM ANTIBODIES DIRECTED AGAINST Gb₃ INDUCE APOPTOSIS IN VERO AND HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC). † 2150

Introduction: The mechanism of vascular endothelial injury in Hemolytic Uremic Syndrome (HUS) has been speculated to be direct toxin-mediated damage. We propose an alternate hypothesis, in which a natural auto-antibody idiotypic network plays a central role in the damage of vascular endothelium.

Purpose: Our objective was to determine if serum anti-Gb₃ (α-Gb₃) antibodies induce damage to HUVEC and VERO cells.

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