Partial Liquid Ventilation (PLV) and Conventional Gas Ventilation(GV) : Histopathologic differences in newborn piglet lungs in a Meconium Aspiration Syndrome (MAS) model 1591

Introduction: PLV has been reported to lessen airway and alveolar injury in animals and humans. Clinical benefit has been demonstrated with PLV therapy in MAS in animals. This prospective randomized non-blinded controlled laboratory study evaluated the effects of GV and PLV on lung histopathology in the newborn piglet MAS model.

Methods: Twenty-four piglets were anesthetized, ventilated and instrumented. Post meconium instillation, the hypoxic and acidotic piglets(1-4 days age; 1-2 kg wt) were randomly assigned to one of the two groups and were studied for 4 hours. 5 piglets each from GV and PLV groups were also randomized to receive 40ppm inhaled NO.

• GV Conventional positive pressure gas ventilation with 100% O₂

• PLV FRC filled with perfluorodecalin and ventilated with 100% O₂

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