NEAR INFRARED SPECTROSCOPY-MEASURED CHANGES IN CEREBRAL BLOOD VOLUME(ΔCBV) AND CYTOCHROME AA3 (ΔCytaa3) IN NEWBORN LAMBS DURING HYPOXIA AND ISCHEMIA † 1760

We investigated the relation between brain perfusion/tissue oxygenation andΔCBV (mL/100g)/ΔCytaa3 (μM) during hypoxia (HYPOX) and hypotension (HYPO) in 33 newborn lambs by comparing changes in carotid flow(ΔQcar: mL/min) and cerebral O2 consumption (ΔCMRo2: mL O2/min-1) with ΔCBV and ΔCytaa3 during ventilation with 6-8% O2 during 30 min, and during subsequent additional HYPO (<35 mmHg for 5 min) and normoxic reperfusion (RP).

Conclusions: ΔCBV estimates changes in brain perfusion, but overestimates brain perfusion during hypotension. The pattern of ΔCytaa3 suggests less oxygen utilisation by brain tissue during hypoxia and during subsequent reperfusion.

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