Intravenous immunoglobulin (IvIg) infusions take 3-4 hours, if the instructions of the producer are followed, and the patients and parents have to spend considerable time at the hospital. The tolerance of IvIg infusions given at a rate that would allow an infusion of 0.5 g/kg to be completed within 1-1.5 hours have been investigated in an open, prospective, randomized study.

Method: 22 patients, 15 children and 7 adults, with primary or secondary immunodeficiencies participated. After one uneventful infusion of 0.5 g/kg IvIg (Gammonativ®) each patient was given 4 infusions at«normal» infusion rate (4 ml/kg per hour for children) and 4 at an increased rate (maximum 10 ml/kg per hour).

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