Abstract 58

Background: Adhesion of leukocytes to endothelial cells during the immune response to pathogens is a tightly regulated, multistep process involving selectin-mediated rolling and integrin-dependent firm adhesion. Previously, we and others have shown that L-selectin expressed on leukocytes is a signal transducing receptor in addition to its known function as mediator of leukocyte rolling. In particular, we identified activation of the small G-protein Ras upon L-selectin triggering, resulting in cytoskeletal changes and synthesis of oxygen radicals. In order to identify downstream target molecules of Ras, we tested, whether cellular stimulation of T-lymphocytes activates kinases involved in cellular stress reactions (stress activated protein kinase (SAPK) and p38-kinase (p38-K)).

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