Effects of IL-1 on the expression of surfactant proteins are dependent on degree of maturity

Abstract 222

Amniotic fluid concentrations of proinflammatory cytokines, particularly IL-1, are increased in preterm labor during intraamniotic infections. Infants prenatally exposed to chorioamnionitis are less likely to have respiratory distress syndrome (RDS) than controls. However, after birth, high IL-1 in airway specimens is associated with surfactant dysfunction, and with development of chronic lung disease (CLD). We have shown that intraamniotic of IL-1α (150-1500 ng) promotes maturation of the fetal lung by enhancing the expression of surfactant proteins SP-A and SP-B and improving the dynamic compliance (J Clin Invest 99:2992, 1997).

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD