Abstract 1921 Poster Session I, Saturday, 5/1 (poster 86)

Inhaled nitric oxide, in combination with high concentrations of oxygen, is administered to newborn infants for the treatment of pulmonary hypertension. Although there have been several controlled trials showing efficacy of inhaled nitric oxide in infants, there has not been a large amount of work looking at the combined oxidative effects of inhaled nitric oxide and oxygen. Therefore, the purpose of this study was to investigate the effects of prolonged exposure of neonatal rats to the combination of inhaled nitric oxide and greater than 95% oxygen. In addition, due to emerging evidence that oxidant-induced gene products may play vital roles in the lung's adaptive and/or protective responses to oxidative stress, we examined the effect of inhaled nitric oxide on the stress response protein, heme oxygenase-1 (HO-1).

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account
Continue with Google
Continue with ORCiD