Abstract
The role of myeloperoxidase (MPO) for vasculitis formation accompanied with the production of MPO-specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) was analyzed using wild and MPO-deficient mice. MPO-ANCA levels in sera of wild type C57BL/6 mice with vasculitis particularly in the coronary arteries induced by injection of (Candida albicans-derived substances (CADS) increased. The MPO-ANCA titers in sera were significantly higher in vasculitis-positive mice than in vasculitis-negative mice, indicating that MPO-ANCA was closely associated with vasculitis formation. However, the increase of MPO-ANCA titers observed in sera of wild C57BL/6 mice were strongly suppressed in MPO-deficient C57BL/6 mice, accompanied with prevention of vasculitis formation. These results show that MPO acted as an antigen for MPO-ANCA production by CADS injection and was followed by the vasculitis formation. Vasculitis did develop in a few MPO-deficient mice, though the incidence of vasculitis was much lower in MPO-deficient mice than in C57BL/6 mice. This result suggests that other antigens structurally similar to MPO may also exist.
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ishida-Okawara, A., Oharaseki, T., Takahashi, K. et al. Contribution of Myeloperoxidase to Coronary Artery Vasculitis Associated with MPO-ANCA Production Induced by Candida albicans -Derived Substances. Pediatr Res 53, 175 (2003). https://doi.org/10.1203/00006450-200301000-00129
Issue date:
DOI: https://doi.org/10.1203/00006450-200301000-00129
