Abstract
Oxidant/antioxidant imbalance plays an important role in septic shock. The present study examined changes in circulating oxidative components in a neonatal sepsis model. Subjects were 14 newborn mixed-strain piglets randomly divided into two groups: a cecal ligation and perforation (CLP) model (n = 7) and sham (n = 7). Blood samples for total hydroperoxide (TH), biological antioxidant potential (BAP), tumor necrosis factor (TNF) α, interleukin (IL)-6, and IL-10 were collected pre-CLP and at 1, 3, and 6 h post-CLP. TH and BAP levels at 1 h post-CLP were significantly higher in the CLP group than in the sham group. In the CLP group, TH decreased gradually and reached baseline levels by 6 h post-CLP, while BAP remained elevated. Linear correlations were identified between serum TH and BAP at 1 h post-CLP, serum TH and TNF-α at 1 h post-CLP, and BAP and IL-6 at 6 h post-CLP. Changes in and correlations between circulating oxidative and inflammatory state components in a neonatal sepsis model were clarified. This is the first study to reveal that the presence of oxidant/antioxidant imbalance in sepsis and septic shock changes during the disease course.
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Abbreviations
- BAP:
-
biological antioxidant potentials
- CLP:
-
cecal ligation and perforation
- LPS:
-
lipopolysaccharide
- ROS:
-
reactive oxygen species
- TH:
-
total hydroperoxide
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Kakita, H., Hussein, M., Daoud, G. et al. Total Hydroperoxide and Biological Antioxidant Potentials in a Neonatal Sepsis Model. Pediatr Res 60, 675–679 (2006). https://doi.org/10.1203/01.pdr.0000245911.79943.8a
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DOI: https://doi.org/10.1203/01.pdr.0000245911.79943.8a
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