Abstract
In very low birth weight (VLBW) infants, acute renal impairment (ARI) is common, but there is no consensus about criteria for its diagnosis. Neutrophil gelatinase-associated lipocalin (NGAL) is an early and sensitive indicator of renal impairment in experimental animals, children, and adults. Urinary NGAL (UNGAL) is detectable in VLBW infants; however, there is no reference range in this population. The objective of this study is to define the reference range for UNGAL in VLBW infants with no risk factors for acute renal impairment. UNGAL concentration was determined in urine samples collected from day of life (DOL) 4 through DOL 30 in 50 newborns with uncomplicated clinical courses, selected from a total of 145 prospectively enrolled appropriate for gestational age inborn VLBW premature infants. The birth weight and gestational age ranges were 790-1490 g and 26–33 wk, respectively. The median, 95th and 99th percentiles, and range of pooled UNGAL values were 5 ng/mL, 50 ng/mL, 120 ng/mL, and 2–150 ng/mL, respectively. Greater variability and higher quantile levels of UNGAL were observed in females versus males. In conclusion, a reference range for UNGAL in VLBW infants, similar to that in children and adults, has been established.
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Abbreviations
- ARI:
-
acute renal impairment
- DOL:
-
day of life
- GFR:
-
glomerular filtration rate
- NGAL:
-
neutrophil gelatinase-associated lipocalin
- [SCreat]:
-
serum creatinine concentration
- UNGAL:
-
urinary neutrophil gelatinase-associated lipocalin
- VLBW:
-
very low birth weight
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Acknowledgements
Assistance in collecting daily urine samples was provided by Allison R. Polland, BS, Kristin M. Capone, BS, and Patrick L. Scarborough, BS. Shlomo Kuperman, BS, and Matthew O'Rourke, MD, provided technical help and assisted in data entry.
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Supported by Grant UL1 RR024156 from the National Center for Research Resources; Grants DK-55388 and DK-58872 from the National Institute of Diabetes and Digestive and Kidney Diseases (J.B.); and grants from the Emerald Foundation and the March of Dimes.
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Huynh, T., Bateman, D., Parravicini, E. et al. Reference Values of Urinary Neutrophil Gelatinase-Associated Lipocalin in Very Low Birth Weight Infants. Pediatr Res 66, 528–532 (2009). https://doi.org/10.1203/PDR.0b013e3181baa3dd
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DOI: https://doi.org/10.1203/PDR.0b013e3181baa3dd
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