Abstract
Small birth weight and excess of early protein intake are suspected to enhance later adiposity. The present study was undertaken to determine the impact of diets differing in protein content on short-term growth, adipose tissue development, and the insulin-like growth factor (IGF) system in piglets. Normal (NW) and small (SW) birth weight piglets were fed milk-replacers formulated to provide an adequate (AP) or a high protein (HP) supply between 7 and 28 d of age. The fractional growth rate was higher (p < 0.01) in SW than in NW piglets. At 7 d of age, the lower (p < 0.05) weight of perirenal adipose tissue relative to body mass in SW than in NW piglets did not involve significant changes in plasma IGF-I, leptin, or insulin-like growth factor binding protein levels, but involved differences (p < 0.05) in the expression of IGF-I and leptin in adipose tissue. Growth rates did not differ between AP and HP piglets. At 28 d of age, HP piglets had lower (p < 0.001) relative perirenal adipose tissue weight but did not differ clearly from AP piglets with regard to the IGF system. It remains to be determined whether piglets fed such a high protein intake will stay subsequently with a low adiposity.
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Abbreviations
- A-FABP:
-
adipocyte (A)-type fatty acid binding protein
- AP:
-
adequate protein formula
- CPT-I:
-
carnitine-palmitoyl transferase (CPT)-I
- FAS:
-
fatty acid synthase
- GLUT4:
-
glucose transporter 4
- HP:
-
high protein formula
- NW:
-
normal birth weight
- SW:
-
small birth weight
- PPAR-γ:
-
peroxisome proliferator-activated receptor gamma
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Acknowledgements
The authors thank N. Auriou and C. Weiss (PTC-Konolfingen, Switzerland) for the production of milk-replacers, and E. Bobillier and G. Savary for the conception, production, and maintenance of milk feeders. The authors also acknowledge C. Tréfeu for her expert technical assistance; M. Alix, J. Liger, and J.F. Rouaud for animal slaughtering; and A. Chauvin, B. Janson, F. Le Gouevec, V. Piedvache, and H. Renoult for animal surgery and care.
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Supported, in part, by INRA and Nestec.
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Morise, A., Sève, B., Macé, K. et al. Impact of Intrauterine Growth Retardation and Early Protein Intake on Growth, Adipose Tissue, and the Insulin-Like Growth Factor System in Piglets. Pediatr Res 65, 45–50 (2009). https://doi.org/10.1203/PDR.0b013e318189b0b4
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DOI: https://doi.org/10.1203/PDR.0b013e318189b0b4
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