1070 Precocious Detection of Metabolic Bone Disease

Abstract

Introduction: The improvement of care allowed that LBW infants survive. Among of the routine cares that we must have in the control of these infants it is the detection of the metabolic disease of the prematury (MBD). There are guidelines that use only the serum evaluation of calcium, phosphorus and alkaline phosphatase, excluding the urinary evaluation.

Objectives: Comparison of the urinary investigation and the serum about the precocity of the alterations detection that characterize the MBD.

Method: Prospective cohorte study of the newborn admitted in the neonatal intensive care unit in the period of nine (9) months, with low birth weight lower than 1.500 grams. With two weeks of life the urine collection was made for calcium, phosphorus, creatinine (ratio calcium/phosphorus) and calcium, phosphorus and serum.

Results: Sixteen children had been analyzed, with average of weight of birth of 1.263 g (lower weight: 970g, greater weight: 1485g). The urinary alterations had been precocious in 62.5% of the sample of the study. There were not simultaneous urine and blood alterations. With the altered examination the therapeutical treatment was instituted: replacement of calcium and phosphorous via administration.

Conclusions: In our cohorte was identified bigger precocity of identification in the compatible laboratorial alteration with MBD when using the urinary investigation of seric eletrolyte. With the findings of the study we decided to use as a routine, only the urinary investigation, which will diminish the number of painful procedures (venous or arterial blood collection) and the withdrawal of sanguine volume.

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