Abstract
We examined the association between elevated concentrations of 25 blood proteins in blood spots collected on postnatal d 1, 7, and 14 from infants <28 wk gestation who survived to 24 mo and the risk of two patterns of early lung disease i.e. early and persistent pulmonary dysfunction (EPPD) and normal early pulmonary function followed by pulmonary deterioration (PD). Thirty-eight percent (n = 347) of our cohort had PD, and 43% (n = 383) had EPPD. On postnatal d 14, elevated concentrations of two proteins (RANTES and VEGF) were associated with reduced risk of PD. Similarly, the risk of EPPD was also reduced if three proteins had elevated concentrations on postnatal d 14 (RANTES, MMP-1, and VEGF). In contrast, the risk of EPPD was increased if on d 14 two proteins had elevated concentrations (IL-8 and ICAM-1). Inflammation might influence the risk of EPPD and PD or be a consequence of lung damage or therapies to minimize lung dysfunction.
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Abbreviations
- CLD:
-
chronic lung disease
- ELGAN:
-
extremely low GA newborn
- EPPD:
-
early and persistent pulmonary dysfunction
- FiO2:
-
fraction of inspired oxygen
- MCP:
-
monocyte chemoattractant protein
- MIP:
-
macrophage inflammatory protein
- MMP:
-
matrix metalloproteinase
- PD:
-
pulmonary deterioration
- SAA:
-
serum amyloid A
- VCAM:
-
vascular cell adhesion molecule
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Acknowledgements
The authors wish to acknowledge their ELGAN study colleagues:
Olaf Dammann, Tufts Medical Center, Boston MA; Bhavesh L. Shah, Baystate Medical Center, Springfield MA; Camilia Martin, Beth Israel Deaconess Medical Center, Boston MA; Robert Insoft, Brigham & Women's Hospital, Boston MA; Karl Kuban, Boston Medical Center, Boston, MA; Francis Bednarek, U Mass Memorial Health Center, Worcester, MA; John Fiascone, Tufts Medical Center, Boston MA; Richard Ehrenkranz, Yale-New Haven Children's Hospital, New Haven CT; T. Michael O'Shea, Wake Forest University/Baptist Medical Center, Winston-Salem NC; Stephen C. Engelke, University Health Systems of Eastern Carolina, Greenville NC; Carl Bose, The University of North Carolina, Chapel Hill NC; Mariel Poortenga, Ed Beaumont, DeVos Children's Hospital, Grand Rapids MI; Nigel Paneth, Sparrow Hospital, Lansing MI; Michael D. Schreiber, University of Chicago Hospital, Chicago IL; Daniel Batton, William Beaumont Hospital, Royal Oak MI; Greg Pavlov, Frontier Science and Technology Research Foundation, Amherst, NY, and our project officer, Deborah Hirtz.
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Supported by a cooperative agreement with NINDS 5U01NS040069. Supported by the Thrasher Research Fund [C.B.].
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Laughon, M., Bose, C., Allred, E. et al. Patterns of Blood Protein Concentrations of ELGANs Classified by Three Patterns of Respiratory Disease in the First 2 Postnatal Weeks. Pediatr Res 70, 292–296 (2011). https://doi.org/10.1203/PDR.0b013e3182274f35
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DOI: https://doi.org/10.1203/PDR.0b013e3182274f35
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