Milstone and colleagues assessed the potential neurotoxicity of chlorhexidine on the developing central nervous system using a well-established in vitro model of neurite outgrowth. It was found that chlorhexidine at concentrations detected in the blood following topical application in preterm infants specifically inhibited L1-mediated neurite outgrowth of cerebellar granule neurons.

See Chlorhexidine inhibits L1 cell adhesion molecule–mediated neurite outgrowth in vitro

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